Myles Bradbury, 41, of Herringswell in Suffolk, admitted abusing 18 children in his care at Addenbrooke's Hospital in Cambridge, between 2009 and 2013.
Bradbury has admitted 25 offences, including sexual assault, voyeurism and possessing more than 16,000 indecent images.
The judge told him his offences were a "gross and grotesque breach of trust".
Sentencing him at Cambridge Crown Court, Judge Gareth Hawkesworth said: "In many years on the bench, I've never come across a more culpable or grave course of sexual criminality which has involved such a gross and grotesque breach and betrayal of your Hippocratic Oath and trust reposed in you by your patients."
The judge told Bradbury, a blood cancer specialist who was arrested in December 2013, he had no doubt he had caused psychological harm to his victims and was at risk of doing so in future.
A victim's account of an examination by Dr Bradbury
"He would ask to get me in the room on my own, and say I'm old enough to go in a room on my own, says one of the victim.
"And then he'd want to check me.
"Instead of checking just my joints, he'd want to check my whole body.
"He'd make me strip down.
"He focused on my private parts."
Canadian authorities had alerted the UK's Child Exploitation and Online Protection Centre (Ceop) in July 2012 that Bradbury had bought a DVD containing indecent images of children, but Ceop did not pass on the information until November 2013.
In September, he pleaded guilty to six counts of sexual assault and 13 counts of engaging in sexual activity with a child.
Bradbury also admitted three counts of causing or inciting a child to engage in sexual activity, one count of voyeurism and two counts of making indecent images of a child.
He was a charming intellectual with a grotesque secret.
Myles Bradbury hid his depravity from everyone. No-one suspected a thing - not even his wife, his hospital colleagues or worshippers at his local church.
But the consultant also fitted the profile of a paedophile - someone who goes out of his way to get access to children. His choice of profession, and his decision to work in an African AIDS orphanage.
He's lost a £100,000 career, his wife has separated from him, taking their new child with her.
He only answered "no comment" in police interviews. So we may never know how many boys he molested.
His greatest claim to fame was that he once met the Queen. Now he will be detained at her pleasure for a very long time.
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